The left-armer was a mainstay of the Yorkshire side that dominated English cricket from the end of the 1950s through the 1960s at a time when only players born within the county boundaries were allowed to wear the White Rose.
He took 1,189 first-class wickets at 21.00 in 422 first-class matches and helped Yorkshire win seven County Championship titles.
He took 100 wickets in three of those seasons and five times in total.
Wilson also played in six Tests for England, although these were spread over a seven-year period, with five coming away to India in 1964 before his final appearance against New Zealand in Christchurch in 1971.
In all, he took 11 Test wickets.
Wilson also played twice for England against the Rest of the World in 1970, matches later stripped of Test status by the International Cricket Council
He was also Yorkshire Players' Association president in 2008.
A Yorkshire statement said: "Sad news has reached the club this (Saturday) afternoon of the death of Don Wilson, aged 74.
"Don died in York Hospital at 1pm (1200GMT) this afternoon.